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My research field or area of interest innanotechnology
toxicity of methanol, made by ADH1 enzyme into formaldehyde inside human cells in 20 tissues -- from cigarette smoke, aspartame, fruits juices vegetables in cans and jars -- Prof. Woodrow C. Monte paradigm, WhileScienceSleeps.com
Interest in...
low cost nanodevices for citizen use to measure ethanol, methanol, acetaldehyde, formaldehyde, formic acid, formate in beverages, foods, saliva, tears, blood, urine, air
Publication list
http://www.WhileScienceSleeps.com for Prof. Woodrow C. Monte, Food Science and Nutrition, Arizona State University, retired 2004 -- free online archive of 782 full text references
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methanol (wood alcohol) from aspartame and cigarettes is made into formaldehyde inside cells by ADH1 enzyme in 20 specific human tissues, including islets of Langerhans -- WC Monte paradigm: Rich Murray 2013.07.19

Methanol (wood alcohol), from aspartame, cigarette smoke, and unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers, goes to all parts of the body every minute with the blood flow, with half-life 3 hours -- it readily enters all cells in body and fetus, just as does ethanol.

Humans are uniquely vulnerable, as their cells lack the enzymes that in all other animals prevent ADH1 enzyme from rapidly making methanol into free floating formaldehyde right inside the cells of 20 specific tissues, including the islets of Langerhans in the pancreas, where insulin is produced. As free floating formaldehyde, molecule by molecule, rapidly binds firmly on both sides to the nearest DNA, RNA, and large proteins in a cell, the cell malfunctions and dies. Gradually the chronic low level toxicity impairs the production and functioning of insulin.

#6 diabetes 2 risk high for 2 cans aspartame diet drink weekly 14
years 66K women study, Guy Fagherazzi et al AJCN 2013 Jan -- methanol
(cigarettes, aspartame) formed into formaldehyde inside cells in
pancreas by ADH1 enzyme, WC Monte paradigm: Rich Murray 2013.02.13

ADH1 is "unusually highly concentrated" in the million tiny "isles of Langerhans" in the pancreas, where the beta cells make insulin -- cigarette use correlates with diabetes 2 risk, with a doubling of risk for smoking over a pack daily.
[ page 172, "While Science Sleeps", 2012 January, Prof. Woodrow C. Monte, Food Science and Nutrition, Arizona State University, retired 2004 ]

WhileScienceSleeps.com includes free online archive of 782 full text medical research references:


http://www.whilesciencesleeps.com/pdf/637.pdf 5 pages

Baehler R., Pestalozzi D., Hess M., Von Wartburg JP.
Immunohistochemical localization of alcohol dehydrogenase in human kidney, endocrine organs and brain.
Pharmacol Biochem Behav. 1983;
18 Suppl 1:55-9 1983;18(Suppl 1):55-9.

http://www.whilesciencesleeps.com/pdf/648.pdf 12 pages

Willi C., Bodenmann P., Ghali WA., Faris PD., Cornuz J.
Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis.
JAMA 2007;298(22):2654-64.

http://www.whilesciencesleeps.com/pdf/283.pdf 5 pages

Wei M, Gibbons L, Mitchell T, Kampert J, Blair S.
Alcohol intake and incidence of type 2 diabetes in men.
Diabetes Care 2000;23(1):16-21. Ming Wei mwei@cooperinst.org

Many of these diseases, including diabetes 2, are twice as harmful for those who never drink ethanol, compared to those who have just one standard drink a day, due to the inhibition by ethanol of formation of formaldehyde from methanol by ADH1.

Many people are protected by ethanol in their blood from fermentation by bacteria in the GI tract.

autism as a birth defect from epigenetic methylation by formaldehyde made from methanol by ADH1 enzyme inside Purkinje cells in vermis in cerebellum and in inner walls of brain blood vessels -- Prof. WC Monte paradigm: Rich Murray 2013.04.26

California OEHHA sets methanol ingestion level 23 mg daily, same as from 1 can aspartame diet soda, 10 cigarettes, 3 tomatoes, or 4 cans green beans: Rich Murray 2013.07.03

"However, the anticipated exposure to methanol from consumption of aspartame would not be considered an exposure within the meaning of Proposition 65 because aspartame is not listed under Proposition 65. "

[ Rich Murray: Many pregnant women drink one 12-oz can aspartame diet drink daily, with 200 mg aspartame that gives 11% methanol, 22 mg, which is just under the OEHHA limit of 23 mg daily.

The smoke from 10 cigarettes gives 20 mg methanol, the same as from 3 full size fresh tomatoes, or 4 cans of green beans. ]

See also:

James McDonald to EFSA, outdated aspartame ADI gives methanol 35 times too high for human safety, ten minute talk at April 9 public sharing, Brussels: Rich Murray 2013.04.15

aspartame harm in rat brain from 75 mg/kg gives human ADI 0.75 mg/kg, 53
times less than EU ADI 40 mg/kg, Ashok Iyyaswamy, SheelaDevi Rathinasamy,
U. Madras 2012.08.03 free full text -- main methanol toxin is formaldehyde,
not formate: Rich Murray 2013.06.01

more lower aspartame and methanol ADIs from studies by RH Nair, SheelaDevi
Rathinasamy, WC Monte, PS Jeganathan, A Namasivayam, Hazleton Labs, Searle
Labs: Rich Murray 2013.06.01

11% of aspartame is methanol, which becomes free floating formaldehyde inside human cells -- methanol also in cigarettes and canned fruits and vegetables: Rich Murray 2013.07.16

The Woodrow C. Monte methanol/formaldehyde toxicity paradigm is that
concentrations of ADH1 enzyme, well known to exist inside blood vessel
wall cells in specific tissues, quickly turn methanol into
formaldehyde inside the vessel cells, in humans only -- the highly
reactive formaldehyde diffuses to penetrate adjacent tissue cells,
binding to DNA, RNA, and proteins, attracting macrophages, which die,
creating complex, expanding micro lesions, leading to many modern
"diseases of civilization", Alzheimer's, arthritis, diabetes, multiple
sclerosis, lupus -- as well as later cancers -- also serious birth
defects in the fetal brain in the fourth week of pregnancy, spinal
bifida and autism.

Aspartame is 11% methanol, 22 mg per can of diet drink -- similar
levels of methanol come from wood and cigarette smoke, heated and
canned fruits juices vegetables, fermented and smoked foods, some
wines and liquors, vehicle fuels, many cleaners and solvents, chemical
medical autopsy mortuary facilities, heated wood in particleboard and
paper factories, and more.

similar macular harm in multiple sclerosis as from formaldehyde made
by ADH enzyme inside retina capillary walls from methanol, Prof.
Woodrow C. Monte text "While Science Sleeps" 2012 Jan -- some quotes
re retina harm: Rich Murray 2012.05.10

aspartame impairment of spatial cognition and insulin sensitivity in
mice, focus on phenylalanine and aspartate [ methanol also crosses
placenta into fetus, turning into teratogenic formaldehyde], Kate S.
Collision et al, PLoS One 2012.04.03: Rich Murray 2012.04.29

WC Monte submits submits robust evidence for multiple sclerosis, which he concludes proves methanol to be the proximate toxic cause, since ADH1 enzyme is within the cells of the inner linings of brain blood vessels, the Purkinje cells of the vermis of the cerebellum, and rods and cones of the retina -- ADH1 quickly turns methanol into free floating formaldehyde within these cells, disrupting the blood brain barrier...

The public EFSA session on aspartame safety on April 9 for 5 hours included an audience of about 50 experts and 10-20 ESFA staff in Brussels.

The release of the final EFSA review on aspartame safety will be delayed from April 15 to November, 2013.

Extremely cogent multiple lines of robust evidence were briefly described that strongly support the methanol formaldehyde toxicity paradigm of Prof. Woodrow C. Monte, Prof. Food Science and Nutrition, Arizona State University, retired 2004 -- supported by an online archive of 782 free full text medical research references atwww.WhileScienceSleeps.com .

It is clear that methanol is far more dangerous for chronic low level exposures than realized since 1890.

Major sources include the smoke from a pack of cigarettes, 40 mg methanol,the same as from 2 cans aspartame diet drink. It now seems likely that most cigarette diseases are actually methanol toxicity...

Methanol stays in the blood with a half-life of 3 hours, reaching every part of the body and the fetus with the bloodstream, and readily entering all cells.

Humans are uniquely vulnerable to methanol formaldehyde toxicity, as they lack a functioning catalase enzyme system, that in all other creatures serves to protect each cell against the rapid conversion of methanol into free floating formaldehyde right inside the cells of 20 specific tissues that have high levels of ADH1 enzyme.

The effects are used to good advantage in embalming and disinfection, as formaldehyde immediately bonds to and impairs DNA, RNA, and proteins, permanently disrupting cell biochemistry, cell by cell, as long as methanol is ingested -- leading to 20 specific chronic modern novel "diseases of civilization", that progress slowly and erratically, according to the ingestion of methanol from a variety of modern sources:

smoke from cigarettes, wood, and peat;

since 1983, aspartame, including from most chewing gums;

fresh tomatoes and black currants;

unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers;

jams jellies marmalades;

smoked fermented spoiled foods;

many dark wines and liquors;

work at paper and wood factories, mortuaries, medical and chemical facilities;

Research since 2012 specifically shows the presence of formaldehyde bonded to cellular macromolecules inside cells after methanol ingestion -- the paradigm will be confirmed in detail very quickly, as science exponentially explores this simple breakthrough.

This presents the world food industry with an unprecedented opportunity to serve the huge public good by collaborating vigorously to eliminate all methanol exposures from foods and beverages. The Net guarantees that the news and evidence will spread explosively everywhere.

Paul Thomas MD Pediatrics & Integrative Medicine, Portland OR, praises
"While Science Sleeps" at Amazon.com -- WC Monte paradigm of methanol
formaldehyde toxicity via ADH1 enzyme in 20 human tissues, including fetus: Rich Murray 2013.04.03

autism as a birth defect from epigenetic methylation by formaldehyde made from methanol by ADH1 enzyme inside Purkinje cells in vermis in cerebellum and in inner walls of brain blood vessels -- Prof. WC Monte paradigm: Rich Murray 2013.04.26

highly competent, pithy analysis of aspartame cancer study by Eva S.
Schernhammer at Harvard, William R. Ware, PhD, showing relevance of
Woodrow C. Monte methanol-formaldehyde toxicity paradigm: Rich Murray

Prof. Resia Pretorius letter re aspartame to EJCN cites Prof. Woodrow C.
Monte "While Science Sleeps" text, re methanol/formaldehyde toxicity
paradigm: Rich Murray 2012.05.21

Aspartame: The hidden danger [methanol/formaldehyde] in our midst and how it kills us, 12 page review of While Science Sleeps text (Woodrow C Monte), International Health News, whole June issue, Editor: William R Ware PhD: Rich Murray 2012.06.08

Table 5.2 is the key chart -- ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21

"As a matter of course, every soul citizen of Earth has a priority to
quickly find and positively share evidence for healthy and safe food,
drink, environment, and society."

within the fellowship of service,

Rich Murray,
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
254-A Donax Avenue, Imperial Beach, CA 91932-1918,
505-819-7388 cell,
619-623-3468 home,

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