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Lucafò Marianna
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  • Trieste, Italy
  • Italy
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I am...
My research field or area of interest innanotechnology
Selective drug delivery by a variety of functionalized drug carriers is the most effective approach to provide the therapeutic concentration of anticancer drugs to the target cancer cells to improve the therapeutic efficacy for tumor tissues. Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Derivatized fullerenes could be used in biomedical applications and can be suitable vectors for drug delivery due to their small size, large surface area and good solubility. Cytotoxicity studies, carried on 5 different fullerenes and the mechanism of cellular uptake are the subjects of this study with the purpose to identify the most appropriate fullerene carrier for anticancer drug delivery. The cytotoxicity of the 5 fullerenes was tested on the human mammary carcinoma cell line MCF7 and on its multidrug resistant MCF7/ADR. The choice of these cell is based on our objective to conjugate the anticancer drug adriamycin to the fullerene vector in order to overcome adriamycin resistance.
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Researchgroup, Institute, University, School, Company name
Sava's Team, University of Trieste
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