"Here is a recent article that uses AFM in conjunction with Raman Spectroscopy, they claim resolution all the way down to 2-10 nm by adjusting the angle of incidence of the excitation field.
"In addition to the other advice already given:
1) Reduce the physical size of your sample as small as possible. More mass = more thermal vibrations.
2) Reduce the temperature of your sample (and room) as much as feasible and comfortably…"
"They must be taking advantage of various sub-diffraction "cheats", similar to what is used with confocal microscopy to break the optical resolution limit, for example. OP, you should post the article that makes the claim, at least."
"You need to narrow your question down, considerably. What nanoparticles, of which dimensions? What type of lasers, specifically what output spectrum and what hertz?
I would go out on a limb here and venture that there is…"
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