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Dr.Shamrez Ali
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Dr.Shamrez Ali commented on Natalia Nanorf.ru's blog post Russian scientists to cover viruses in gold
"Its Quite interesting and will open new frontiers."
Jun 1, 2011

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Dr.Shamrez Ali commented on Natalia Nanorf.ru's blog post Russian scientists to cover viruses in gold
"Quite intresting"
Jun 1, 2011

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Dr.Shamrez Ali commented on ASHISH PATIL's video
Mar 26, 2011

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Dr.Basavaraj K.Nanjwade and Dr.Shamrez Ali are now friends
Mar 12, 2011

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Mar 10, 2011

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Dr.Shamrez Ali liked Dr.Basavaraj K.Nanjwade's blog post Regulatory and Industry Requirements for Botanical Drug Products
Mar 10, 2011

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Dr.Shamrez Ali liked Dr.Basavaraj K.Nanjwade's blog post Drug Stability and Stabilization Techniques
Mar 10, 2011

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Dr.Shamrez Ali liked Dr.Basavaraj K.Nanjwade's blog post Enhancing Drug Bioavailability by Overcoming Intestinal Metabolism
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Dr.Shamrez Ali updated their profile
Feb 25, 2011

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Dr.Shamrez Ali replied to TINC's discussion Looking for PhD or Postdoc position
"I had completed My PhD in pharmaceutical Dosage form Science and it delivery and having the practical experience in pharma industry of 9 years  and looking for for a Post Doc Position in nanotech or Crystal Engineering.    "
Feb 24, 2011

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Dr.Shamrez Ali was featured
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Dr.Shamrez Ali is now a member of The International NanoScience Community
Feb 22, 2011

Profile Information

I am...
Doctor
My research field or area of interest innanotechnology
In Co-Crystals , Poly morphs, Nano particles, Enhancement of Bio-Availability, Pharmaceutical Process Technology , Innovation @ work and Research.
Interest in...
In Co-Crystals , Poly morphs, Nano particles, Enhancement of Bio-Availability, Pharmaceutical Process Technology , Innovation @ work and Research.
Publication list
Preparation and solid-state characterization of leflunomide polymorph along with its solubility assessment and dosage form dissolution author ALI M Shamarez A Swati 2010
62nd IPC (Indian pharmaceutical Congress), Manipal, Karnataka , INDIA


Leflunomide is a DMARD (Disease –Modifying Antirheumatic Drug) . It is used for the treatment of rheumatoid arthritis. It exhibits four polymorphic forms I, II, III, IV. Leflunomide is a drug with a limited water solubility(21 mg/L). In the present study , a more soluble polymorph (form II) was formulated using a less soluble polymorph (form I)and then the rate of dissolution of the tablets of both were compared. There was a significant difference between the melting point of both the forms. Form I and form II was 166.5°C, 83°C respectively. The crystals of form II polymorph were characterized by IR, DSC and XRPD. IR 3355 cm-1 is a characteristic band of form II. Comparison of solubility of form I and form II was done by UV spectrophotometer. A significant increase in the solubility of leflunomide form II was seen. The absorbance solution of form II in water (10µg/ml) was found to be 0.686 at λmax 258 nm whereas absorbance of form II was found to be 0.390.There was increase in solubility of form II by 75%. Aqueous film coated tablets of both the forms were made by using same processing parameters and compared for the rate of dissolution. The form II tablets show a significant improvement in terms of drug release and solubility. Thus, form II polymorph and tablets were successfully developed and it was concluded that form II is a desirable form for use in pharmaceutical compositions in terms of solubility and dissolution rate.


We are working on the Single Crystallographic studies.



Leflunomide, Polymorphism, XRPD, DSC, IR

ref1


2010


Effect of Tropical Climatic Conditions on the Stability of Cefaclor Dry Powder for Suspensions M Shamrez Ali Basavaraj K
Nanjwade

Abstract: Purpose: Two critical factors that govern the stability of pharmaceutical formulations in the tropics are humidity and temperature. This study was carried out to investigate the effect of moisture sorption at two different storage conditions on Cefaclor dry powder for oral suspension and predict the effect of moisture interaction on the reconstituted formulations Method: Cefaclor dry powder for suspension formulation was taken as a model formulation for this study. Different formulations were manufactured and placed in twelve amber coloured glass bottles for each test condition. One set of bottles was sealed by heat induction technique under vacuum to ensure the integrity of the seal while the other set was without a seal but had a child-resistant cap. Both types of bottles were stored in humidity chambers at 30°C/65%RH or 40°C/75%RH. Weight changes were monitored on a dynamic moisture balance over a period of 3 months. Results: The results were recorded in terms of moisture content, colour, and excipient interaction and their effect on product appearance. The data were analyzed using Students t-test and one way analysis of variance (ANOVA), and differences were considered statistically significant at P < 0.05. Conclusions: The study revealed that the product with enhanced packaging and also contained nonwater soluble colourants were more protected against the deleterious effects of moisture and temperature. The findings provide an insight into a possible approach for formulating moisture-sensitive pharmaceutical products, especially dry powder preparations for use in the tropics.

Dry powder for suspension, Moisture content, Colour, (all 6 tags) Stability, Moisture migration, Interaction.

February 9 1 73 -79

Isolation and Characterization of Antibiotic Production from Soil Isolates by Fermentation




M
Shamrez
Ali


author




S
Chandrashekhara


author




B
K
Nanjwade


author




P
S
Goudanavar


author




F
V
Manvi


author




2010-Jan-Feb

text






Research Journal of Pharmaceutical Dosage Form and Technology




continuing

periodical
academic journal



Abstract: In screening of new antibiotics, several actinomycetes were isolated from soil samples. Crowded plate technique was used for the isolation of actinomycetes. The morphological and cultural characterization of A-4 strain was performed. In medium formulation study for A-4 and A-4 mutant, various carbon and nitrogen sources were tested for maximum antibiotic production using zone of inhibition and packed cell volume (%) as parameters. Various fermentation conditions like pH, temperature and DO2 were also optimized for the maximal production of antibiotic from both A-4 and A-4 mutant. All medium formulation as well as bioprocess parameters for A-4 and A-4 mutant strains was compared. Some actinomycetes strains, showed promising antimicrobial scores against different strains of bacteria and fungi. From the six strains selected, one strain designated as A-4 showed maximum antimicrobial property against gram positive and gram negative strains as well as various fungi. Morphological and cultural studies showed that A-4 is belongs to actinomycete genus.. The strain A-4 and A-4 mutant was found to be having better antimicrobial activity in comparison with other soil isolates of actinomycetes.





Actinomycete, Antibiotic, Crowded plate technique, (all 5 tags) Zone of Inhibition, Fermentation


ref3


2010-Jan-Feb


2



1



32
36









A New Stability - Indicating RP-HPLC Method to Determine Etamsylate in Injection Formulation




M
Shamrez
Ali


author




S
Chandrashekar


author




Prakash
Goudannavar


author




Basavaraj
K
Nanjwade


author




Mahibub
M
Kanakal


author




Yusrida
Darwis


author






text






International Journal of Pharmaceutical and Biological Archive




continuing

periodical
academic journal



A simple and accurate Reverse Phase High-Performance Liquid Chromatography (RPHPLC) method was developed to determine Etamsylate in injection formulations. The drug was chromatographed on a reversed phase C-18 column. Eluents were monitored at a wavelength of 220 nm using a mixture (40:60) Methanol: Buffer (phosphate buffer). Solution concentrations were measured on weight basis to avoid the use of an internal standard. The method was spastically validated for linearity, accuracy, precision and selectivity. Due to its simplicity and accuracy, method will be useful for routine quality control analysis.





RP-HPLC, Selectivity, Accuracy, (all 5 tags) Precision, Stability Indicating method


ref4




http://www.ijpba.info/ijpba/index.php/ijpba/article/viewFile/46/26




XXXX-june


1



2



140
143









Effect of Compression Pressure on Dissolution and Solid State Characterization of Cefuroxime Axetil




M
Shamrez
Ali


author




Basavaraj
K
Nanjwade


author




Veerendra
K
Nanjwade


author




F
V
Manvi


author




2011-Jan

text






Journal of Analytical and Bioanalytical Techniques




continuing

periodical
academic journal



The current work aims to investigate the sudden drop of dissolution with respect to higher compression pressure and hardness of tablet with a good and comparative less significant disintegration time and to understand an affect of pressure on drug with respect to compression behavior on dissolution and other properties. Where Cefuroxime Axetil was compressed at different pressure in form of pellets and tablets using hydraulic press and compression machine respectively, and characterized to understand any physical and chemical change using X-ray powder diffraction, differential scanning calorimetry, Dissolution and Scanning Electron microscopy. Scanning electron microscopy studies of pellets revealed that the change in surface morphology from opaque to translucent clear with increase in breaking force, these different pressure compressed pellets were subjected to uniform reduction of particle size. The similarity factor f2 values of drug release profile were comparably same. The breaking force and pellet hardness had indicated a very firm intrinsic binding force exist with Cefuroxime Axetil, study had investigated the decrease in-vitro dissolution is marked by the compact binding property of individual particles of Cefuroxime Axetil between the excipient due to the increase in compression force.





Pressure effect, compression, dissolution, (all 5 tags) Cefuroxime Axetil, thermal analysis.


ref5




http://www.omicsonline.org/2155-9872/2155-9872-1-112.pdf




2011-Jan


1



3



1000112
Researchgroup, Institute, University, School, Company name
SIMPEX PHARMA
Researchgroup, Institute, Company, University, School webpage
http://innovators-welcome.com
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Publications by A. Paszternák:

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pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

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Directed Deposition of Nickel Nanoparticles Using Self-Assembled Organic Template,

Organometallic deposition of ultrasmooth nanoscale Ni film,

Zigzag-shaped nickel nanowires via organometallic template-free route

Surface analytical characterization of passive iron surface modified by alkyl-phosphonic acid layers

Atomic Force Microscopy Studies of Alkyl-Phosphonate SAMs on Mica

Amorphous iron formation due to low energy heavy ion implantation in evaporated 57Fe thin films

Surface modification of passive iron by alkylphosphonic acid layers

Formation and structure of alkylphosphonic acid layers on passive iron

Structure of the nonionic surfactant triethoxy monooctylether C8E3 adsorbed at the free water surface, as seen from surface tension measurements and Monte Carlo simulations