Dear Nanotechnology Researchers,
Can anyone tell me that what are all the toxicological studies i can do with different nanoparticles.If anybody can answer for this it will be very usefull for my research.
Dear Nanotechnology Researchers,
Can anyone tell me that what are all the toxicological studies i can do with different nanoparticles.If anybody can answer for this it will be very usefull for my research.
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Replies
I am also a Microbiologist, and very much new in to nanotech... i think when we talk about nanostructures the primary mechanism of its toxicity is in its small (nano) form, i.e. particles with new physics e.g: increased surface area to vol ratio, eventually making that particular nanoparticle with high chemical and biological activity... the greater chemical reactivity reselts in increased production of Reactive Oxygen Species (ROS), including free radicals...evident in case of C-60, CNTs, and metal oxides.. ultimate result is oxidative stress, inflamation and damage to proteins membs, and DNA. the extremely small size of nanomaterials also means that they are much more readily taken up by the body, able to cross biological membs, and access cells, tissues and organs that larger sized particles normally cannot...nanoparticles can gain access to the blood stream following inhalation or ingestion.. broken skin is an ineffective particle barrier, enable skin uptake of nanomaterials more readily.. once in blood stream, they can transported around the body and taken up by organs and tissues such as heart, liver, kidneys, spleen, nervous system... (Nano) Size is therefore a key factor in determining the potential toxicity of a particle... however it is not the sole factor..as discussed by Mr. Debasis...
sry for very late reply...
Regards,
Amod...
whether particle shape interfere with toxicity?
I am also very new to the nanotechnology. Am a microbiologisat. What u r disscussing exactly covering the topics wat am thinking.Can u tell me something about this mutagenesis.