I guess that solely depends on the what kind of nanoparticles you are planning to work on. For example, metallic nanoparticles such as Ag, are shown less toxicity compared to semiconducting nanoparticles. Of couse, Cd and Hg are highly poisonous. Among semiconducting nanoparticles, chalconides (S, Se, Te) are found to be more toxic compared to oxide based nanoparticles. However, some oxide based nanoparticles, such as silica, are found to be toxic at certain doses. Bottomline is toxicity depends on several paramenters: composition, element, particle size, loading, functionalization etc.
Recently I read an article on nano-toxicology in NanoToday "Can cells reduce nanoparticle toxicity?" by Huw Summers, (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B82X8-...).
The authors describes that the cell can recover itself in certain cases from toxicity. An example of quantum dots is also mentioned. It is small article but quite intriguing. Have a look!
There is report (Novel Materials in the Environment: The case of nanotechnology(2008)) form The Royel Commission on Environment Pollution on several aspects of novel material. One of the chapters (Chapter 3) addresses the in vivo impact of nanoparticles. If you are interested you can have a look: http://www.rcep.org.uk/reports/27-novel%20materials/documents/Novel...
There's very few studies done in toxicological effects of nanomaterials in marine environments. I'm doing a research project on marine red algae (Ag). It depends on what particles your interested in and which angle you are coming from (environmental, human health, ecological-like bioaccumulation). Tell me what you are interested in and send me an e-mail at firstname.lastname@example.org.
Hello, I am doing also a researh on marine algae (dead red algae, Porphyta or Nori) and another alga Valisneria americana, and I hope to see if them have removal proprieties for heavy metal ions. If them form metal nanoparticles, I hope to be good for depoluting water.
sir... i am very new in nanotechnology but being a biotechnologist,i can say that cytotoxicity studied, like LDH assay, MTT assay, DNA fragmentation assay,etc that are carried out on human cell lines,may be usefull. also some bacteriological assays like AMES test for mutagenecity are also usefull.
Thank you very much mam.....
I am also very new to the nanotechnology. Am a microbiologisat. What u r disscussing exactly covering the topics wat am thinking.Can u tell me something about this mutagenesis.
I am also a Microbiologist, and very much new in to nanotech... i think when we talk about nanostructures the primary mechanism of its toxicity is in its small (nano) form, i.e. particles with new physics e.g: increased surface area to vol ratio, eventually making that particular nanoparticle with high chemical and biological activity... the greater chemical reactivity reselts in increased production of Reactive Oxygen Species (ROS), including free radicals...evident in case of C-60, CNTs, and metal oxides.. ultimate result is oxidative stress, inflamation and damage to proteins membs, and DNA. the extremely small size of nanomaterials also means that they are much more readily taken up by the body, able to cross biological membs, and access cells, tissues and organs that larger sized particles normally cannot...nanoparticles can gain access to the blood stream following inhalation or ingestion.. broken skin is an ineffective particle barrier, enable skin uptake of nanomaterials more readily.. once in blood stream, they can transported around the body and taken up by organs and tissues such as heart, liver, kidneys, spleen, nervous system... (Nano) Size is therefore a key factor in determining the potential toxicity of a particle... however it is not the sole factor..as discussed by Mr. Debasis...
sry for very late reply...
sory for late reply... whatever Mr. Amod has mentioned is right and all the tests that i hav mentioned check for one of those possibible effects of nanoparticles on mammalian cells. the procedure for these tests is very simple and easily available on internet.
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