Is there anyone wants to talk about "Cancer"? I am really interested at it. It is becoming a serious problem day by day. On the other hand, with the development of technology, we will probably find a treatment. I think it is very soon:)
Anyways waiting for your messages.
My personal opinion is that hardly we will find a treatment for cancer, if we do not understand its ethiology. First, we need to answer the following question: What are the pathogens that can have the chance to interact directly with DNA? We know that there are some cancerogenic molecules and radioactive agents that can cause cancer. But there are also particles like asbestos that can induce pleural mesothelioma if inhaled. If we do not understand the cancerogenic mechanism, we cannot find the right therapy and we cannot make prevention.
It my personal opinion that nanoparticles can interact directly with cells and cell components for their tiny size and induce intracellular and nuclear changes. So, from my point of view it is not safe to inject not biodegradable nanoparticles in human bodies (even if in cancerogenic tissue), if there is no certainty to be able to eliminate them from the body. They represent foreign bodies and the body, the tissue, the cell react always against their presence, immediately or in a delayed time. In my capacity of Coordinator of the European Project called DIPNA (Nanotoxicity) I am evaluating the type of interaction that inorganic nanoparticle create inside the cells. For this knowledge I am sure that a not wise use of these nanoparticles can show side effects in humans and in the environment. We had a similar situation when the Curies discovered the radioactive materials. Only 40 years later, we understood the lethal risks of the radiations.
To answer to Mr Satish, I suggest him to analyze his friend's pacreatic samples ( I can analyze them by electron scanning microscopy) and verify if some submichronic foreign bodies are present in the tissue. The chemical composition of them (detect by means of an energy dispersive spectroscopy) can give him the chemical composition of the debris and to understand type of exposure that his friend .
If you need more information you can write me directly .(Nanopathology: the health risk of nanoparticles. (www.nanopathology.it; www.worldscibooks.com/nanosci/v001.html))
Antonietta Gatti. University of Modena
It is sound interesting and well needed topic. I'm very sad about Prof Randy Pausch dead, the professor at Carnegie Mellon University who inspired countless students in the classroom and others worldwide through his highly acclaimed last lecture, has died of complications from pancreatic cancer. He was 47.
from then only i studied (theoretically) some proposal treatments that are how to catch the cancer molecule from our body ( identification of cancer molecule very precision way) and destroy the cancer molecule.
actually I'm student for material Science and Engineering and in the beginner position for medical field too.
We are very interested in cancer - but we are keenly aware that it is such a vast area of research, that just reading the available literature on the general topic is a lifelong task. So we decided to focus on the skills that we feel we master well - which happens to be the effects of light on biological material. We have investigated how UV light is able to modify the chemical structure of proteins - if properly used it opens so-called disulphide bridges. In the open state, other molecules may block these bonds, and prevent the molecules from returning to the native state again. This way we can immobilize proteins onto surfaces with a spatial precision of a few microns. We term the effect LAPI = Light assisted protein immobilization. We have many papers documenting this effect. From a nano perspective we are able to open a 2Å bond by carefully illuminating the protein with a particular wave length for a particular duration. We linked up with a cancer biology group, and illuminated various skin cancer cell lines, and investigated the effect. The first observation was that we induce apoptosis (cell death) in these cells - and that we know exactly why this process was initiated. Interestingly the light modifies the receptor that is also the target for many cancer chemotrapeutic approaches.
Our message is that LAPI appear to be a new, and potentially usefull approach to interfering with the biochemistry growth and proliferation of cancer cells. We are considering several futuristic concepts on how to combine the light approach with smart application of nano particles coated with proteins
We invite anybody with an interest in this approach to contact us at firstname.lastname@example.org
This is basically a nano-science and research community. However i wish to pont out here that Linus Pauling Institute is engaged in the research of tea and vegetable source in treatment of cancer. There are several herbals which are said to have curative properties against cancer.Nowdays pressed for time. anyway put the names of some herbals if some one shows the interest in knowing here.
I am happy this community keeps updated through nice information about nanomedicine and cancer.I am a Nuclear Medicine specialist and molecular imaging specialist and we use PET-CT this is most advanced technology to diagnose cancer at early stage and also helps to stage the disease besides PET can track the changes in the tumor and confidently guide the treating physician about the effect of Chemo and Radiotherapy.
Example I had a patient middle aged lady who suffered from lung tumor and as the tumor spreaded to lymphnode(metastases)the same was treatead with chemotherapy and just after 2 cycles of chemo we detected that the tumor has responded very well(there is quantitative parameter called SUV to track down howmuch the drug or treatment has been effective)We saw that the more than 60% of tumor regressed and this helps treating doctor to continue the same line of treatment or else they change the track(using another line of therapy or adding adjuvent drugs/Radiochemo combination etc).PET or molecular imaging combined with MR can study proteomics and genomics of various diseases.
I am very happy to see this excellent result in our setting.
As for PET study we use labelled molecules eg glucose or thymidine etc there is tremendous future waiting for early diagnosis and treatment too.
Besides tumor this can also diagnose Alzeimer's dimentia which causes early forgetfulness (called presenile dementia).So much so that amyloid plaques can also be detected using suitable agents and PET technology.The future of nanomedicine is great indeed.
with thanks from Manoranjan
Many thanks for the topic, I'm from Sudan this is becoming a serious problem in my country
is there any relation to the heavy use of pesticides and the other chemicals? poor comunities
with no or poor health care are the most affecting people, the medicines are so expencive
I hope we can do somthing in this NanoS.Community to help poor ones
Welcome! Nanopaprika was cooked up by Hungarian chemistry PhD student in 2007. The main idea was to create something more personal than the other nano networks already on the Internet. Community is open to everyone from post-doctorial researchers and professors to students everywhere.
There is only one important assumption: you have to be interested in nano!
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