Replies to This Discussion

Permalink Reply by Antonietta Gatti on December 30, 2008 at 2:43pm

Dear All,

My personal opinion is that hardly we will find a treatment for cancer, if we do not understand its ethiology. First, we need to answer the following question: What are the pathogens that can have the chance to interact directly with DNA? We know that there are some cancerogenic molecules and radioactive agents that can cause cancer. But there are also particles like asbestos that can induce pleural mesothelioma if inhaled. If we do not understand the cancerogenic mechanism, we cannot find the right therapy and we cannot make prevention.
It my personal opinion that nanoparticles can interact directly with cells and cell components for their tiny size and induce intracellular and nuclear changes. So, from my point of view it is not safe to inject not biodegradable nanoparticles in human bodies (even if in cancerogenic tissue), if there is no certainty to be able to eliminate them from the body. They represent foreign bodies and the body, the tissue, the cell react always against their presence, immediately or in a delayed time. In my capacity of Coordinator of the European Project called DIPNA (Nanotoxicity) I am evaluating the type of interaction that inorganic nanoparticle create inside the cells. For this knowledge I am sure that a not wise use of these nanoparticles can show side effects in humans and in the environment. We had a similar situation when the Curies discovered the radioactive materials. Only 40 years later, we understood the lethal risks of the radiations.
To answer to Mr Satish, I suggest him to analyze his friend's pacreatic samples ( I can analyze them by electron scanning microscopy) and verify if some submichronic foreign bodies are present in the tissue. The chemical composition of them (detect by means of an energy dispersive spectroscopy) can give him the chemical composition of the debris and to understand type of exposure that his friend .
If you need more information you can write me directly .(Nanopathology: the health risk of nanoparticles. (www.nanopathology.it; www.worldscibooks.com/nanosci/v001.html))

Antonietta Gatti. University of Modena
antonietta.gatti@unimore.it

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Permalink Reply by Sivasayanth on December 30, 2008 at 2:50pm

It is sound interesting and well needed topic. I'm very sad about Prof Randy Pausch dead, the professor at Carnegie Mellon University who inspired countless students in the classroom and others worldwide through his highly acclaimed last lecture, has died of complications from pancreatic cancer. He was 47.

from then only i studied (theoretically) some proposal treatments that are how to catch the cancer molecule from our body ( identification of cancer molecule very precision way) and destroy the cancer molecule.

actually I'm student for material Science and Engineering and in the beginner position for medical field too.

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Permalink Reply by Arturo E Cadena on December 30, 2008 at 7:48pm

Hello:

I am really interested in this topic. I think that the nanorobotics is a best treatmnet for combat the "Cancer".

Sincerely,
Arturo E Cadena Jr.
Unmanned Vehicle Researcher.

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Permalink Reply by Steffen B. Petersen on December 31, 2008 at 8:52am

Hi Olga,

We are very interested in cancer - but we are keenly aware that it is such a vast area of research, that just reading the available literature on the general topic is a lifelong task. So we decided to focus on the skills that we feel we master well - which happens to be the effects of light on biological material. We have investigated how UV light is able to modify the chemical structure of proteins - if properly used it opens so-called disulphide bridges. In the open state, other molecules may block these bonds, and prevent the molecules from returning to the native state again. This way we can immobilize proteins onto surfaces with a spatial precision of a few microns. We term the effect LAPI = Light assisted protein immobilization. We have many papers documenting this effect. From a nano perspective we are able to open a 2Å bond by carefully illuminating the protein with a particular wave length for a particular duration. We linked up with a cancer biology group, and illuminated various skin cancer cell lines, and investigated the effect. The first observation was that we induce apoptosis (cell death) in these cells - and that we know exactly why this process was initiated. Interestingly the light modifies the receptor that is also the target for many cancer chemotrapeutic approaches.

Our message is that LAPI appear to be a new, and potentially usefull approach to interfering with the biochemistry growth and proliferation of cancer cells. We are considering several futuristic concepts on how to combine the light approach with smart application of nano particles coated with proteins

We invite anybody with an interest in this approach to contact us at sp@nano.aau.dk

please check out these pages on our web-site :
http://www.nanobio.dk/research.asp?mid=48&sid=148
http://www.nanobio.dk/showms.asp?mid=55&sid=247
http://www.nanobio.dk/research.asp?mid=48

A happy new year to all who reads this

Steffen B. Petersen

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Permalink Reply by K. MOHAN on December 31, 2008 at 2:58pm

This is basically a nano-science and research community. However i wish to pont out here that Linus Pauling Institute is engaged in the research of tea and vegetable source in treatment of cancer. There are several herbals which are said to have curative properties against cancer.Nowdays pressed for time. anyway put the names of some herbals if some one shows the interest in knowing here.

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Permalink Reply by TINC on January 3, 2009 at 11:19am

Two new forum topics related to this:

Prevention is better than cure-boosting one's immune system is to w... by K. MOHAN

Cancer and nanotechnology by Asher Cron

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Permalink Reply by TINC on February 3, 2009 at 7:23pm

‘Nanotechnology can cure cancer’

http://www.nanopaprika.eu/profiles/blogs/nanotechnology-can-cure-ca...

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Permalink Reply by Manoranjan Chowhan on April 28, 2009 at 9:59am

I am happy this community keeps updated through nice information about nanomedicine and cancer.I am a Nuclear Medicine specialist and molecular imaging specialist and we use PET-CT this is most advanced technology to diagnose cancer at early stage and also helps to stage the disease besides PET can track the changes in the tumor and confidently guide the treating physician about the effect of Chemo and Radiotherapy.
Example I had a patient middle aged lady who suffered from lung tumor and as the tumor spreaded to lymphnode(metastases)the same was treatead with chemotherapy and just after 2 cycles of chemo we detected that the tumor has responded very well(there is quantitative parameter called SUV to track down howmuch the drug or treatment has been effective)We saw that the more than 60% of tumor regressed and this helps treating doctor to continue the same line of treatment or else they change the track(using another line of therapy or adding adjuvent drugs/Radiochemo combination etc).PET or molecular imaging combined with MR can study proteomics and genomics of various diseases.
I am very happy to see this excellent result in our setting.
As for PET study we use labelled molecules eg glucose or thymidine etc there is tremendous future waiting for early diagnosis and treatment too.
Besides tumor this can also diagnose Alzeimer's dimentia which causes early forgetfulness (called presenile dementia).So much so that amyloid plaques can also be detected using suitable agents and PET technology.The future of nanomedicine is great indeed.
with thanks from Manoranjan

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Permalink Reply by TINC on May 9, 2009 at 11:14am

Some links to this topic:

Nanotechnology kills cancer cells

http://news.bbc.co.uk/2/hi/health/4734507.stm

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Nanotechnology and Cancer

http://cancerweb.ncl.ac.uk/cancernet/400388.html

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Permalink Reply by sudania2000 on May 24, 2009 at 8:49am

Many thanks for the topic, I'm from Sudan this is becoming a serious problem in my country
is there any relation to the heavy use of pesticides and the other chemicals? poor comunities
with no or poor health care are the most affecting people, the medicines are so expencive
I hope we can do somthing in this NanoS.Community to help poor ones
Regards
Sudania

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Permalink Reply by TINC on July 23, 2009 at 7:56pm

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Permalink Reply by Gyan Singh Shekhawat on August 20, 2009 at 7:50am

hi

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